Orlistat works in the digestive system and acts as a Lipase enzyme inhibitor. This inhibition reduces the amount of Triglycerides that are hydrolysed into absorbable fatty acids, the unchanged Triglycerides are then excreted from the body in the faeces. Orlistat, in combination with a healthy diet and exercise, can thus promote weight loss.
Orlistat is to used to aid weight loss however it needs to be used in combination with a low fat diet and exercise. A Chochrane review study demonstrated that not only can Orlistat lead to moderate weight loss, but it can also reduce diabetes incidence, improve cholesterol and lower blood pressure.
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It can useful for those individuals that are genetically prone to increased weight, especially those that are already obese.
Orlistat should be avoided in higher fat diets and higher fat meals because it can lead to 'oily stools' and flatulence. It should be taken three times daily 20 minutes before meals, a dose should be omitted if the meal is knowingly high in fat e.g fast food, conversely a dose should also be omitted if the meal contains no fat e.g salad. Always refer to the product literature.