Pioglitazone, also sold under brand names such as Actos, is a medicine which is part of the thiazolidinedione class, a class of medicines used clinically to manage diabetes. Pioglitazone is an anti-diabetic medicine used to treat non-insulin dependent type 2 diabetes mellitus when metformin is either considered to be unsuitable or inadequate for lowering patients' blood sugar levels. Pioglitazone works by reducing insulin resistance in the liver and peripheral tissues which leads to a reduction in glucose production in the liver and lowers circulating levels of blood sugar.
Pioglitazone works rapidly to bring blood sugar levels under control in situations where changes to diet, and exercise have proven to be ineffective or have poor patient compliance. It can be used either to replace or as an adjunct to treatment with the glucose disposal agent metformin.
It is recommended that patients first attempt to control their diet and exercise programs to bring blood sugar under control but where this is not achieved, Pioglitazone can be prescribed. Currently, Pioglitazone is only recommended as a treatment to adults. Furthermore, there is some tentative evidence that it can also be effective in the treatment of fatty liver although this is considered an experimental treatment at this stage.
Pioglitazone should be taken as directed by your doctor. In general, Pioglitazone is taken as a single 30mg tablet once a day either with or without food. Always refer to product literature. Always refer to product literature.