Tranylcypromine, originally sold under the trade name of Parnate, is a type of anti-depressant which has a fairly unique profile and effects relative to other anti-depressants. It is classed as a monoamine oxidase inhibitor (MAOI), being a non-selective and irreversible inhibitor of MAO. This makes it fairly distinctive in a treatment class characterised principally by SSRI type drugs such as Prozac. The mechanism of action of Tranylcypromine leads to an increase in serotonine, norepinephrine and dopamine which is relatively unusual for anti-depressants which tend not to target either dopamine or norepinephrine.
Due to its unique actions, Tranylcypromine is often used not solely to treat depression but also anxiety disorders. Indeed, Tranylcypromine has been shown to also have a neuroprotective effect in those with Parkinson's disease. With a long history of use it provides a compelling alternative to those who do not respond well to SSRI's, TCAs and similar drugs. Unlike most anti-depressants Tranylcypromine does not tend to cause weight gain, the opposite in fact, most likely due to its stimulating properties.
Tranylcypromine is used to treat major depressive disorders including atypical depressions and is often a favoured treatment where there is an anxiety component to the depression. Those concerned about weight gain may also be better off using Tranylcypromine.
Tranylcypromine is generally dosed on a daily schedule but dosing may be adjusted by the patient's physician.Always refer to product literature.